Mega Drive / Genesis - S
- Sagaia
- Saint Sword
- Sampras Tennis 96
- Samurai Shodown
- Saturday Night Slam Masters
- Schöne und das Biest
- Scooby-Doo Mystery
- SD Valis
- seaQuest DSV
- Second Samurai
- Secret of Monkey Island
- Secret of Shinobi
- Separation Anxiety
- Shadow Dancer
- Shadow Dancer - Legend of Shinobi
- Shadow of the Beast
- Shadow of the Beast 2
- Shadowrun
- Shanghai 2 - Dragon's Eye
- Shaq Fu
- Shining Force
- Shining Force 2
- Shining in the Darkness
- Shinobi 3
- Shove it - the Warehouse Game
- Shove It! the Warehouse Game
- Simpsons - Bart's Nightmare
- Sir Gallahad
- Skeleton Krew
- Skitchin'
- Slaughter Sport
- Snow Brothers
- Sol Deace
- Sol-Deace
- Soldiers of Fortune
- Soleil
- Son of Chuck Rock
- Sonic & Knuckles
- Sonic 1
- Sonic 2
- Sonic 3
- Sonic 3D Blast
- Sonic Classics 3 in 1
- Sonic Spinball
- Sonic the Hedgehog
- Sonic the Hedgehog 2
- Sonic the Hedgehog 3
- Sonic und Knuckles
- Space Harrier 2
- Space Invaders '91
- Space Invaders 90
- Space Invaders 91
- Sparkster
- Spider-Man
- Spider-Man - Separation Anxiety
- Spider-Man & Venom - Maximum Carnage
- Spider-Man & Venom - Separation Anxiety
- Spider-Man and Venom - Separation Anxiety
- Spider-Man vs. the Kingpin
- Spirou
- Splatterhouse 2
- Splatterhouse 3
- Sports Talk Football
- Spot Goes To Hollywood
- Squirrel King
- Star Trek - Deep Space Nine
- StarFlight
- Stargate
- Steel Empire
- Stormlord
- Story of Thor
- Street Fighter 2 - Special Champion Edition
- Street Racer
- Streets of Rage
- Streets of Rage 2
- Streets of Rage 3
- Strider
- Strider Returns - Journey from Darkness
- Subterrania
- Sunset Riders
- Super Battleship
- Super Fantasy Zone
- Super Hang On
- Super Hang-On
- Super Hydlide
- Super League
- Super Monaco GP
- Super Street Fighter 2
- Super Thunder Blade
- Super Volleyball
- Sword of Sodan
- Sword of Vermillion
- Syd of Valis
- Sylvester and Tweety in Cagey Capers
- Syndicate