Mega Drive / Genesis - M
- M-1 Abrams Battle Tank
- M.U.S.H.A.
- Madden 92
- Madden 95
- Madden NFL '94
- Madden NFL '95
- Madden NFL '96
- Madden NFL '97
- Madden NFL '98
- Madden NFL 96
- Madden NFL 97
- Madden NFL 98
- Mario Andretti Racing
- Mario Lemieux Hockey
- Marko's Magic Football
- Marsupilami
- Marvel Land
- Master of Monsters
- Maximum Carnage
- Mazin Saga
- McDonald's Treasureland Adventure
- me Park
- Mega Bomberman
- Mega Lo Mania
- Mega SWIV
- Mega Trax
- Mega Turrican
- Mega Twins
- Menacer
- MERCS
- Michael Jackson's Moonwalker
- Mick & Mack - Global Gladiators
- Mick and Mack - Global Gladiators
- Mickey Mania
- Mickey Mouse - World of Illusion
- Mickey to Minnie Magical Adventure
- Micro Machines
- Micro Machines 2
- Micro Machines 2 - Turbo Tournament
- Micro Machines 96
- Midnight Resistance
- MIG 29
- MIG-29
- Might and Magic
- Mighty Morphin Power Rangers
- Mighty Morphin Power Rangers - the Movie
- Mike Ditka's Power Football
- Mondu's Fighting Palace
- Monopoly
- Monster World 4
- Mortal Kombat
- Mortal Kombat 2
- Mortal Kombat 3
- Mr. Nutz
- Ms. Pac-Man
- Muhammad Ali's Heavyweight Boxing
- Musha
- Mutant League Football
- Mutant League Hockey
- Mystical Fighter