Mega Drive / Genesis - E
- E-Swat
- Earnest Evans
- Earthworm Jim
- Earthworm Jim 2
- Ecco 2 - the Tides of Time
- Ecco Jr.
- Ecco Jr.'s Great Ocean Treasure Hunt
- Ecco the Dolphin
- Ecco the Dolphin 2 - the Tides of Time
- El Viento
- Elemental Master
- Eliminate Down
- ESPN National Hockey Night
- ESWAT - City Under Siege
- Eternal Champions
- European Club Soccer
- Evander Holyfield's "Real Deal" Boxing
- Evander Holyfield's Real Deal Boxing
- Ex Mutants
- Ex-Mutants
- Exile
- Exo Squad