Nintendo DS - S
- SaGa 3 - Jikuu no Hasha - Shadow or Light
- Saka-Tsuku DS - Touch and Direct
- Sakutto Hama Reru Hori Hori Action - Mr. Driller
- Sam Power - Handyman
- San Goku Shi Taisen DS
- Sands of Destruction
- Sarah's Emergency Room
- SBK - Snowboard Kids
- Science Papa
- Scooby Doo! Who's Watching Who?
- Scooby-Doo - First Frights
- Scooby-Doo! - Geheimnisvolle Abenteuer
- Scooby-Doo! - Wer schaut wem zu?
- Scooby-Doo! and the Spooky Swamp
- Scooby-Doo! und der Spuk im Sumpf
- Scooby-Doo! Unmasked
- Scrabble
- Scribblenauts
- Scurge - Hive
- SD Gundam G Generation DS
- Sea Park Tycoon
- Sea World - Shamu's Big Adventure
- SeaWorld - Shamu's Deep Sea Adventures
- Secret Files 2 - Puritas Cordis
- Secret Saturdays - Beast of the 5th Sun
- Sega Casino
- Sega Superstars Tennis
- Seiken Densetsu - Heroes of Mana
- Sekaiju No Meikyuu
- Sekaiju No Meikyuu 2 - Shoou No Seihai
- Settlers
- Shaberu! DS Oryouri Navi
- Shakugan no Shana DS
- Shantae - Risky's Revenge
- Shashin De Kakutou! Photo Fighter 10
- Shaun the Sheep
- Shaun White Snowboarding
- Sherlock Holmes - Mystery of the Mummy
- Shin Megami Tensei - Devil Survivor
- Shin Megami Tensei - Strange Journey
- Shining Force Feather
- Showtime Championship Boxing
- Shrek - Ogres and Dronkeys
- Shrek der Dritte
- Shrek Forever After
- Shrek Smash and Crash
- Shrek SuperSlam
- Shrek the Third
- Shrek's Carnival Craze
- Shunkan Puzz Loop
- Sid Meier's Civilization Revolution
- Sideswiped
- Sight Training
- Sigma Harmonics
- SimAnimals
- SimAnimals - Africa
- SimAnimals Africa
- SimCity Creator
- SimCity DS
- Simpsons Game
- Sims 2
- Sims 2 - Apartment Pets
- Sims 2 - Apartment-Tiere
- Sims 2 - Castaway
- Sims 2 - Gestrandet
- Sims 2 - Haustiere
- Sims 2 - Pets
- Sims 3
- Six Flags Fun Park
- Skate It
- Slime MoriMori - Dragon Quest 2 - Daisensha To Shippo Dan
- Slingo Quest
- Smart Kid's Gameclub
- Smiley World Island Challenge
- SNK vs. Capcom Card Fighters DS
- Snood 2 - On Vacation
- Snood 2 - Snoods on Vacation
- Snowboard Kids DS
- Solatorobo - Red the Hunter
- SomaBringer
- Sonic & Sega All-Stars Racing
- Sonic and Sega All-Stars Racing
- Sonic Chronicles - the Dark Brotherhood
- Sonic Classic Collection
- Sonic Colors
- Sonic Colours
- Sonic Rush
- Sonic Rush Adventure
- Sophies Freunde - Kochspaß
- Soul Bubbles
- Soul Eater - Medusa no Inbou
- Soul of Darkness
- Space Bust A Move
- Space Bust-A-Move
- Space Chimps
- Space Invaders Extreme
- Space Invaders Extreme 2
- Space Invaders Revolution
- Spectral Force Genesis
- Spectrobes
- Spectrobes - Beyond the Portals
- Spectrobes - Jenseits der Portale
- Speed Racer
- Speed Racer - the Videogame
- Spellbound
- Spelling Challenges and More!
- Spider-Man - Battle for New York
- Spider-Man - Edge of Time
- Spider-Man - Freund oder Feind
- Spider-Man - Friend Or Foe
- Spider-Man - Shattered Dimensions
- Spider-Man - Web of Shadows
- Spider-Man 2
- Spider-Man 3
- Spiderwick Chronicles
- Spitfire Heroes
- Splinter Cell - Chaos Theory
- Spongebob and Friends - Battle for Volcano Island
- SpongeBob Schwammkopf - Atlantis
- SpongeBob Schwammkopf - Kreatur aus der krossen Krabbe
- SpongeBob SquarePants - Creature from Krusty Krab
- SpongeBob SquarePants - Creature/Krusty Krab
- SpongeBob SquarePants - Globs of Doom
- SpongeBob SquarePants - the Yellow Avenger
- SpongeBob SquarePants and Friends - Unite!
- SpongeBob SquarePants Featuring Nicktoons - Globs of Doom
- SpongeBob SquarePants Frantic Fry Cook
- SpongeBob und Freunde - Angriff der Spielzeugroboter
- SpongeBob und Freunde - Durch dick und dünn
- SpongeBob und Freunde - Schlacht um die Vulkaninsel
- Spongebob und seine Freunde - Angriff der Spielzeugroboter
- SpongeBob's Atlantis SquarePantis
- SpongeBob's Surf & Skate Roadtrip
- SpongeBob's Truth or Square
- SpongeBobs Atlantisches Abenteuer
- Spore
- Spore Creatures
- Spore Hero Arena
- Spotto!
- Sprung
- Spyro - Shadow Legacy
- Spyro Shadow Legacy
- Squeeballs Party
- Star Fox Command
- Star Trek - Tactical Assault
- Star Wars - Battlefront - Elite Squadron
- Star Wars - Episode 3 - Revenge of the Sith
- Star Wars - Lethal Alliance
- Star Wars - Shadow Strike
- Star Wars - the Clone Wars
- Star Wars - the Clone Wars - Jedi Alliance
- Star Wars - the Force Unleashed
- Star Wars - the Force Unleashed 2
- Star Wars Episode 3 - Revenge of the Sith
- Star Wars the Force Unleashed 2
- Starship Defense
- Starship Patrol
- Steal Princess
- Steel Horizon
- Strawberry Shortcake - Strawberryland Games
- Street Football
- Style Boutique
- Style Butique
- Style Savvy
- Subbuteo
- Sudoku Ball Detective
- Sudoku DS - Nikoli no Sudoku Ketteiban
- Sudoku Gridmaster
- Sudoku Mania
- Sudoku Master
- Sudokuro
- Suikoden Tierkreis
- Suite Life of Zack & Cody - Tipton Trouble
- Summon Night - Twin Age
- Summon Night 2
- Summon Night Twin Age - Seireitachi no Kyoumei
- Super Black Bass Fishing
- Super Collapse 3
- Super Dodgeball Brawlers
- Super Fruit Fall
- Super Mario 64 DS
- Super Mario Bros.
- Super Monkey Ball - Touch & Roll
- Super Monkey Ball - Touch and Roll
- Super Monkey Ball Touch & Roll
- Super Monkey Ball Touch and Roll
- Super Princess Peach
- Super Robot Taisen K
- Super Robot Taisen OG Saga - Endless Frontier
- Super Robot Taisen OG Saga - Mugen no Frontier EXCEED
- Super Robot Taisen W
- Super Scribblenauts
- Super Speed Machines
- Superman Returns
- Superman Returns - the Videogame
- Surf's Up
- Survival Kids
- Survival Kids - Lost in Blue
- Survival Kids - Lost in Blue 2