Nintendo DS - E
- EA Playground
- Earthworm Jim
- Eco Creatures - Save the Forest
- Ecolis
- Ed, Edd & Eddy - Scam of the Century
- Ed, Edd n Eddy - Scam of the Century
- Edo Bunka Rekishi Kentei DS
- Egg Monster Heroes
- Eigyoudou
- Eiken-Ou - 2-Kyuuhen
- El Tigre - the Adventures of Manny Rivera
- Elebits - the Adventures of Kai & Zero
- Elebits - the Adventures of Kai and Zero
- Electroplankton
- Elements of Destruction
- Elf Bowling 1 & 2
- Elite Beat
- Elite Beat Agents
- Elite Forces Unit 77
- Emblem of Gundam
- Emergency 2012 - Die Welt am Abgrund
- Emergency Room - Real Life Rescues
- Emma at the Farm
- Emma in the Mountains
- Empire Deluxe
- Empire Earth 2
- Enchanted
- Ender's Game - Battle Room
- Ener-G Dance Squad
- English of the Dead
- Equestrian Training
- Eragon
- Essential Sudoku DS
- Etrian Odyssey
- Etrian Odyssey 2 - Heroes of Lagaard
- Etrian Odyssey 3 - the Drowned City
- EverQuest 2
- Exit
- Eye Q
- Eyeshield 21 - Max Devil Power