Nintendo DS - D
- Daigasso Band Brothers - Jam with the Band
- Daigasso! Band Brothers
- Daigasso! Band Brothers DX
- Dancing With the Stars - We Dance!
- Daniel 10 - the Ultimate Power
- Danny Phantom - Urban Jungle
- Danny Phantom Urban Jungle
- Danshaku
- Danshaku 2
- Daredemo Asobi Taizen
- Dark Spire
- Dark Void Zero
- Dawn of Discovery
- Dawn of Heroes
- Days of Memories
- Days of Memories 2
- de Blob
- De Blob 2
- Dead 'n' Furious
- Dead and Furious
- Deal or No Deal
- Death Jr. and the Science Fair of Doom
- Death Note
- Death Note - Kira Game
- Deca Sports DS
- Deep Aquarium
- Deep Labyrinth
- Defenders of Law, Inc. - Crime in Willburg
- Deltora Quest
- Dementium - the Ward
- Dementium 2
- Densetsu No Stafi 4
- Desktop Tower Defense
- Despicable Me
- Despicable Me - Minion Mayhem
- Destiny Links
- Develish
- Devilish
- Di-Gata Defenders
- Diary Girl
- Diddy Kong Racing
- Diddy Kong Racing DS
- Dig Dug
- Dig Dug - Digging Strike
- Digimon 5
- Digimon Story
- Digimon Story - Lost Evolution
- Digimon Story Moonlight
- Digimon Story Sunburst
- Digimon World - Dawn
- Digimon World - Dusk
- Digimon World Championship
- Digimon World DS
- Digimon World Moonlight
- Digimon World Sunburst
- Diner Dash
- Diner Dash - Sizzle & Serve
- Diner Dash - Sizzle and Serve
- Dino Dini's Soccer
- Dino King Battle - Taiko Kara No Hyouryuusha
- Dino Master
- Dinosaur King
- Dinosaur King - 7 Pieces
- DiRT 2
- Discovery Kids - Dolphin Discovery
- Discovery Kids - Kitten Corner
- Discovery Kids - Parrot Pals
- Discovery Kids - Pony Paradise
- Discovery Kids - Puppy Playtime
- Disgaea DS
- Disney Fairies - Tinker Bell
- Disney Fairies - Tinker Bell and the Great Fairy Rescue
- Disney Fairies - TinkerBell
- Disney Friends
- Disney Pixar Cars - Mater-National Championship
- Disney Princess - Magical Jewels
- Disney's American Dragon - Jake Long, Attack of the Dark Dragon
- Disney's Bolt
- Disney's Chicken Little - Ace in Action
- Disney's Herbie Rescue Rally
- Disney's Kim Possible - Kimmunicator
- Disney's Kim Possible - Global Gemini
- Disney's Kim Possible - Kimmunicator
- Disney's Stitch Jam
- Disney/Pixar's Cars
- Diva Girls - Diva Dancers
- DK Jungle Climber
- Dogz
- Dogz 2
- Dokapon Journey
- Dokidoki Majo Shinpan!
- Don King Boxing
- Don't Cross the Line
- Donkey Kong - Jungle Climber
- Donkey Xote
- Doodle Hex
- Dora the Explorer - Dora Saves the Snow Princess
- Doraemon - Nobita No Shin Makai Daibouken DS
- Double Bloob
- Dr. Kawashima - Mehr Gehirn-Jogging - Wie fit ist Ihr Gehirn?
- Dr. Kawashimas Gehirn-Jogging
- Dr. Kawashimas Gehirn-Jogging - Wie fit ist Ihr Gehirn?
- Dr. Kawishima's Brain Training
- Dr. Reiner Knizia's Brainbenders
- Dr. Reiner Knizias Logik Coach
- Draglade
- Dragon Ball - Origins
- Dragon Ball - Origins 2
- Dragon Ball Kai - Ultimate Butouden
- Dragon Ball Z - Attack of the Saiyans
- Dragon Ball Z - Harukanaru Densetsu
- Dragon Ball Z - Supersonic Warriors 2
- Dragon Booster
- Dragon Hunters
- Dragon Quest - Die Chronik der Erkorenen
- Dragon Quest 4 - Chapters of the Chosen
- Dragon Quest 5 - Hand of the Heavenly Bride
- Dragon Quest 6 - Realms of Revelation
- Dragon Quest 9
- Dragon Quest 9 - Hüter des Himmels
- Dragon Quest 9 - Sentinels of the Starry Skies
- Dragon Quest Heroes - Rocket Slime
- Dragon Quest Monsters - Joker
- Dragon Quest Monsters - Joker 2
- Dragon Tamer - Sound Spirits
- Dragon's Lair
- Dragonology
- Drake & Josh - Talent Showdown
- Drake and Josh - Talent Showdown
- Drama Queens
- Dramatic Dungeon - Sakura Taisen
- Drawn To Life
- Drawn to Life - SpongeBob SquarePants Ed.
- Drawn To Life - SpongeBob SquarePants Edition
- Drawn To Life - the Next Chapter
- Dream Chronicles
- Dream Day - Wedding Destinations
- Dream of Neko
- Dream Pinball 3D
- Dreamer - Horse Trainer
- Dreamer - Puppy Trainer
- Dreamer - Shop Owner
- Dreamer - Zoo Keeper
- DreamWorks Super Star Kartz
- Drift Street International
- Drivers Ed Portable
- Driving Theory Training
- Drone Tactics
- DropCast
- DS
- DS Bimoji Training
- DS Rakubiki Jiten
- DS System
- DSi System
- DTM Race Driver - Create and Race
- Ducati Moto
- Duel Love - Koisuru Otome wa Shouri no Joshin
- Duke Nukem - Critical Mass
- Dungeon Explorer - Warrior of the Ancient Arts
- Dungeon Explorer - Warriors of Ancient Arts
- Dungeon of Windaria
- Dungeon Raiders
- Dynasty Warriors DS - Fighter's Battle