Apple Macintosh - E
- Eight Legged Freaks
- El-Fish
- Enchanter
- Entomorph - Plague of the Darkfall
- Eric's Ultimate Solitaire
- Escape From Monkey Island
- Escape Velocity
- Escape Velocity - Nova
- Escape Velocity - Override
- Escape Velocity Nova
- Europa Universalis 4
- Even More Incredible Machine
- Exile - Escape From the Pit
- Exile 2 - Crystal Souls
- Exile 3 - Ruined World
- Exolon
- Extreme Assault