SNES - E
- E.V.O. Search for Eden
- Earth Defense Force
- Earth Light
- Earthbound
- Earthworm Jim
- Earthworm Jim 2
- Ein Hund namens Beethoven
- Emerald Dragon
- Empire Strikes Back
- Equinox
- Equinox - Solstice 2
- ESPN Speed World
- ESPN Sunday Night Football
- EVO - Search for Eden
- Exhaust Heat
- Exhaust Heat 2
- Extra Innings
- Eye of the Beholder