Nintendo Wii - S
- Sadness
- Safari Adventures - Africa
- Safecracker
- Safecracker - the Ultimate Puzzle Adventure
- Saint
- Sakura Wars - So Long, My Love
- Sam & Max - Season 1
- Sam & Max - Season One
- Samba de Amigo
- Samurai Ghost
- Samurai Shodown
- Samurai Shodown 2
- Samurai Shodown 3 - Blades of Blood
- Samurai Shodown Anthology
- Samurai Showdown Anthology
- Samurai Warriors - Katana
- Samurai Warriors 3
- Samurai Warriors Katana
- SAN-X All-Star Revolution
- Sandy Beach
- Sarah's Emergency Room
- Satisfashion
- SBK-08 Superbike World Championship
- Scarface - the World is Yours
- Scene It? - Ganz großes Kino
- Schweineparty
- Science Papa
- Scooby-Doo! - Geheimnisvolle Abenteuer
- Scooby-Doo! and the Spooky Swamp
- Scooby-Doo! First Frights
- Scooby-Doo! Geheimnisvolle Abenteuer
- Scooby-Doo! und der Spuk im Sumpf
- SCORE International Baja 1000
- SD Gundam - Scad Hammers
- SD Gundam G Breaker
- SD Gundam G Generation Wars
- Sea Monsters - A Prehistoric Adventure
- Secret Files - Tunguska
- Secret Files 2 - Puritas Cordis
- Secret Saturdays - Beast of the 5th Sun
- Secret Saturdays - Beasts of the 5th Sun
- Sega Bass Fishing
- SEGA Superstar Tennis
- Sega Superstars Tennis
- Sengoku Basara - Samurai Heroes
- Sengoku Basara 3 Utage
- Sengoku Musou - Katana
- Sengoku Musou 3
- Sengoku Musou Wave
- Shadow Dancer
- Shadow Land
- Shanghai
- Shaun White Skateboarding
- Shaun White Snowboarding - Road Trip
- Shaun White Snowboarding - World Stage
- Sherlock Holmes - Mystery of the Mummy
- Sherlock Holmes - the Secret of the Silver Earring
- Shikigami No Shiro 3
- Shimano Xtreme Fishing
- Shining Force
- Shining in the Darkness
- Shiren the Wanderer
- Shockman
- Shootanto - Kakohen
- Shooting Tech Demo
- Showtime Championship Boxing
- Shrek der Dritte
- Shrek Smash and Crash
- Shrek the Third
- Shrek's Carnival Craze
- Sid Meier's Civilization Revolution
- Sid Meier's Pirates!
- Sidewinder
- Silent Debuggers
- Silent Hill - Shattered Memories
- SimAnimals
- SimAnimals Africa
- SimAnimals Afrika
- SimCity - Creator
- SimCity Creator
- SIMPLE Series
- Simpsons - Das Spiel
- Simpsons Game
- Sims 2 - Castaway
- Sims 2 - Gestrandet
- Sims 2 - Haustiere
- Sims 2 - Pets
- Sims 3
- Sin and Punishment
- Sin and Punishment - Star Successor
- Six Flags Fun Park
- Skate City Heroes
- Skate it
- Ski & Shoot
- Sky Crawlers - Innocent Aces
- Sky Kid
- Skylanders - Giants
- Skylanders - Spyro's Adventure
- Skylanders - Swap Force
- Skylanders Giants
- Skylanders Spyro's Adventure
- Skylanders Swap Force
- Sled Shred
- Smarty Pants
- Smash Bros Brawl
- Smash Table Tennis
- Smiley World Island Challenge
- Sniper Elite
- SNK Arcade Classics - Volume 1
- SNK Arcade Classics Volume 1
- Snowboard Riot
- Soccer
- Soccer Up!
- Soldier Blade
- Sonic & Sega All-Stars Racing
- Sonic & the Black Knight
- Sonic and Sega All-Stars Racing
- Sonic and the Black Knight
- Sonic and the Secret Rings
- Sonic Colors
- Sonic Colours
- Sonic Riders - Zero Gravity
- Sonic Spinball
- Sonic the Hedgehog
- Sonic the Hedgehog 2
- Sonic the Hedgehog 3
- Sonic the Hedgehog 4 - Episode 1
- Sonic the Hedgehog 4 - Episode 2
- Sonic und der schwarze Ritter
- Sonic und die geheimen Ringe
- Sonic Unleashed
- Sorcery Blade
- Soul Calibur - Legends
- Soul Calibur Legends
- Soul Eater - Monotone Princess
- Soulcalibur Legends
- Space Camp
- Space Chimps
- Space Harrier 2
- Space Invaders Get Even
- Space Station Tycoon
- Span Smasher
- Spectrobes - Der Ursprung
- Spectrobes - Origins
- Speed
- Speed Racer
- Speed Racer - the Videogame
- Spelunker
- Spider-Man - Dimensions
- Spider-Man - Edge of Time
- Spider-Man - Freund oder Feind
- Spider-Man - Friend Or Foe
- Spider-Man - Shattered Dimensions
- Spider-Man - Web of Shadows
- Spider-Man 3
- Spiderwick Chronicles
- Splatterhouse
- Splatterhouse 2
- Splinter Cell - Double Agent
- Splinter Cell Double Agent
- SPOGS Racing
- SpongeBob - Die Kreatur aus der Krossen Krabbe
- Spongebob - Die Kreatur aus der krossen Krabbe
- SpongeBob Schwammkopf - Atlantis
- SpongeBob Schwammkopf - Kreatur aus der krossen Krabbe
- SpongeBob SquarePants - Creature from Krusty Krab
- SpongeBob SquarePants - Creature From the Krusty Krab
- SpongeBob SquarePants Featuring Nicktoons - Globs of Doom
- SpongeBob und Freunde - Angriff der Spielzeugroboter
- SpongeBob's Atlantis SquarePantis
- SpongeBob's Truth Or Square
- SpongeBobs Atlantisches Abenteuer
- Spore
- Spore Helden
- Spore Hero
- Sports
- Sports Island
- Sports Island 2
- Sports Party
- SPRay
- Spy Fox in Dry Cereal
- Spy Games - Elevator Mission
- Spyborgs
- Spyro - Dawn of the Dragon
- Squeeballs Party
- SSX Blur
- Star Fox 64
- Star Parodier
- Star Soldier
- Star Soldier R
- Star Trek - Conquest
- Star Wars - Force Unleashed
- Star Wars - the Clone Wars - Lichtschwertduelle
- Star Wars - the Clone Wars - Republic Heroes
- Star Wars - the Clone Wars
- Star Wars - the Clone Wars - Lightsaber Duels
- Star Wars - the Clone Wars - Republic Heroes
- Star Wars - the Force Unleashed
- Star Wars - the Force Unleashed 2
- Star Wars the Clone Wars - Lightsaber Duels
- StarTropics
- Step to the Beat
- Stonekeep - Bones of the Ancestors
- Stop Stress - A Day of Fury
- Story Hour - Adventures
- Story Hour - Fairy Tales
- Storybook Workshop
- Street Fighter 2 - the World Warrior
- Streets of Rage
- Streets of Rage 2
- Streets of Rage 3
- Strong Bad's Cool Game for Attractive People - Episode 1 - Homestar Ruiner
- Strong Bad's Cool Game for Attractive People - Episode 2 - Strong Badia the Free
- Strong Bad's Cool Game for Attractive People - Episode 3 - Baddest of the Bands
- Strong Bad's Cool Game for Attractive People - Episode 4 - Dangeresque 3 - the Criminal Projective
- Strong Bad's Cool Game for Attractive People - Episode 5 - 8-Bit Is Enough
- Strong Bad's Cool Game for Attractive People Episode 1 - Homestar Ruiner
- Strong Bad's Cool Game for Attractive People Episode 2 - Strong Badia the Free
- Strong Bad's Cool Game for Attractive People Episode 3 - Baddest of the Bands
- Stunt Cars
- Sudoku
- Sudoku Ball Detective
- Sudoku Challenge!
- Summer Athletics
- Summer Athletics - the Ultimate Challenge
- Summer Athletics 2009
- Summer Sports - Paradise Island
- Summer Sports Party
- Summer Stars
- Summer Stars 2012
- Super Air Zonk
- Super C
- Super Castlevania 4
- Super Fruit Fall
- Super Mario 3D World
- Super Mario 64
- Super Mario All-Stars
- Super Mario All-Stars - 25th Anniversary Edition
- Super Mario Bros.
- Super Mario Bros. - the Lost Levels
- Super Mario Bros. 2
- Super Mario Bros. 3
- Super Mario Collection Special Pack
- Super Mario Galaxy
- Super Mario Galaxy 2
- Super Mario Sluggers
- Super Mario Stadium - Family Baseball
- Super Meat Boy
- Super Monkey Ball - Banana Blitz
- Super Monkey Ball - Step & Roll
- Super Monkey Ball - Step and Roll
- Super Paper Mario
- Super Pick Ups
- Super Punch-Out!!
- Super R-Type
- Super Smash Bros. Brawl
- Super Smash Brothers - Brawl
- Super Star Soldier
- Super Swing Golf
- Super Swing Golf - Season 2
- Super Swing Golf Pangya
- Super Swing Golf Season 2
- Super Thunder Blade
- Super Turrican
- Super Turrican 2
- Surf's Up
- Survival Kids Wii
- Sushi Go Round
- Suzumiya Haruhi no Gekidou
- Suzumiya Haruhi no Heiretsu
- Sword of Legendia
- Sword of Vermilion
- Swords
- Swords & Soldiers
- Swords and Soldiers