Nintendo 64 - S
- S.C.A.R.S.
- San Francisco Rush
- San Francisco Rush - Extreme Racing
- San Francisco Rush 2049
- SCARS
- Scooby-Doo! Classic Creepy Capers
- SD Hiryu Stadium
- Sentou No Phoenix 64
- Shadow Man
- Shadowgate
- Shadowgate 64
- Shadowgate 64 - Trials of the Four Towers
- Shadows of the Empire
- SimCity 2000
- SimCity 64
- Sin and Punishment - Successor To the Earth
- Smash Bros.
- Smash Brothers
- Snowboard Kids
- Snowboard Kids 2
- Snwoboard Kids
- South Park
- South Park - Chef's Luv Shack
- South Park Rally
- Southpark
- Space Dynamites
- Space Invaders
- Space Station - Silicon Valley
- Space Station Silicon Valley
- Space Station Sillicon Valley
- Spider-Man
- St. Andrew's Golf
- Star Fox
- Star Fox 64
- Star Soldier
- Star Soldier - Vanishing Earth
- Star Wars - Battle for Naboo
- Star Wars - Episode 1 - Battle for Naboo
- Star Wars - Episode 1 - Racer
- Star Wars - Episode 1 Battle for Naboo
- Star Wars - Episode 1 Racer
- Star Wars - Rogue Squadron
- Star Wars - Shadows of the Empire
- Star Wars Episode 1 - Battle for Naboo
- Star Wars Episode 1 - Racer
- StarCraft 64
- StarFox 64
- Starshot - Space Circus Fever
- Stunt Racer 64
- Super Bowling
- Super Mario 64
- Super Robot Spirits
- Super Robot War 64
- Super Smash Borthers
- Super Smash Bros.
- Super Smash Brothers
- Super Speed Race 64
- Super Speed Racer 64
- Supercross 2000
- Superman
- Sydney 2000