Master System - S
- Sagaia
- Secret Command
- Sega Master System
- Shadow of the Beast
- Shanghai
- Shinobi
- Simpsons - Bart vs. the Space Mutants
- Slap Shot
- Sonic Chaos
- Sonic Spinball
- Sonic the Hedgehog
- Sonic the Hedgehog 2
- Space Harrier
- Space Harrier 3D
- Spider-Man
- Strider
- Super Kick-Off
- Super Monaco GP
- Super Monaco GP 2
- Super Monaco Grand Prix
- Super Monaco Grand Prix 2
- Super Tennis