Game Gear - S
- Samurai Shodown
- Shining Force - the Sword of Hajya
- Shinobi
- Shinobi 2 - the Silent Fury
- Simpsons - Bart vs. the Space Mutants
- Slider
- Smurfs Travel the World
- Sonic Blast
- Sonic Chaos
- Sonic Spinball
- Sonic the Hedgehog
- Sonic the Hedgehog 2
- Space Harrier
- Spider-Man - Return of the Sinister Six
- Star Wars
- Streets of Rage
- Super Star Wars - Return of the Jedi
- Superman - the Man of Steel