Dreamcast - E
- Ecco the Dolphin
- Ecco the Dolphin - Defender of the Future
- ECW - Anarchy Rulz
- ECW - Hardcore Revolution
- ECW Anarchy Rulz
- ECW Hardcore Revolution
- El Dorado Gate - Volume 1
- El Dorado Gate - Volume 2
- El Dorado Gate - Volume 3
- El Dorado Gate - Volume 4
- El Dorado Gate - Volume 5
- El Dorado Gate - Volume 6
- El Dorado Gate - Volume 7
- Elemental Gimmick Gear
- Espion-Age-Nts
- ESPN International Track and Field
- ESPN NBA 2 Night
- ESPN NFL 2K
- ESPN NFL 2K 2
- Eternal Arcadia
- European Super League
- Evil Dead
- Evil Dead - Hail To the King
- Evil Twin
- Evolution
- Evolution - the World of Sacred Device
- Evolution 2
- Evolution 2 - Distant Promise
- Evolution 2 - Far Off Promise
- Exodus Guilty Neos
- Expendable
- Extreme Sports