Commodore 64 - S
- Saboteur
- Saboteur 2
- Sabre Wulf
- Saint Dragon
- Salamander
- Samantha Fox Strip Poker
- Sammy Lightfoot
- Samurai Warrior - the Battles of Usagi Yojimbo
- Sanxion
- Sarakon
- Savage
- Savage Island - Part 1
- Savage Island - Part 2
- Save New York
- Sceptre of Baghdad
- Schlossgeist
- Scooby-Doo
- Scramble
- Scrolls of Abadon
- SDI - Strategic Defence Initiative
- Seafox
- Secret of Kandar
- Secret of the Silver Blades
- Sensitive
- Sentinel
- Sergeant Seymour Robotcop
- Serpent's Star
- Sex Vixens From Space
- Seymour goes to Hollywood
- Shadow of the Beast
- Shadow Skimmer
- Shadow Warriors
- Shadowfire
- Shamus
- Shamus Case 2
- Shaolin's Road
- She-Fox
- Sheep in Space
- Shellshock
- Sherlock - the Riddle of the Crown Jewels
- Shiftrix
- Shockway Rider
- Shoot'em-up Construction Kit
- Silkworm
- SimCity (1989)
- Simpsons
- Sinbad
- Skate or Die
- Skate Rock
- Skramble
- Skull Island
- Sky High Stuntman
- Skyjet
- Slamball
- Slayer
- Sleepwalker
- Slurpy
- Smash TV
- Snake
- Snare
- Snokie
- Solomon's Key
- Son of Blagger
- Sorcerer
- Sorcerer of Claymorgue Castle
- Sorcery
- Space Academy
- Space Action
- Space Crusade
- Space Gun
- Space Harrier
- Space Invaders
- Space Invasion
- Space Pilot
- Space Taxi
- Spaghetti Western Simulator
- Speedball
- Spellbound
- Spellbound Dizzy
- Spelunker
- Spherical
- Sphinx Jinx
- Spike in Transylvania
- Spindizzy
- Spiralon
- Spitting Image
- Split Personalities
- Spore
- Spore (1987)
- Sports-A-Roni
- Spy Hunter
- Spy Who Loved Me
- Squirm
- Squish'em
- Staff of Karnath
- Star Trek
- Star Wars
- Star Wars - the Empire Strikes Back
- Starfighter
- Starlifter
- Starquake
- Starray
- Stealth
- Steel
- Steel Thunder
- Steg the Slug
- Storm Warrior
- Stormlord
- Strange Odyssey
- Strangeloop
- Street Cat
- Strider
- Strider 2
- Strike Force Cobra
- Su Sweet
- Subterranea
- Summer Camp
- Sunburst
- Super Aliens
- Super Breakout
- Super Cycle
- Super Pipeline
- Super Pipeline 2
- Super Scramble
- Super Seymour
- Super Space Invaders
- Super Zaxxon
- Survivor
- Suspect
- Sven
- Swamp Fever
- Swiss Family Robinson
- SWIV