Amiga - S
- Santa's Xmas Caper
- Satan
- Scions of a Forgotten World
- Scorched Tanks
- Secret of Monkey Island
- Secret of the Silver Blades
- Sensible Soccer Edition 92/93
- Sensible World of Soccer
- Sentinel
- Settlers - Serf City
- Sex Vixens From Space
- Shadow Dancer
- Shadow of the Beast
- Shadow of the Beast 2
- Shadow of the Beast 3
- Shadow Sorcerer
- Shadowlands
- Sherlock - the Riddle of the Crown Jewels
- Shiftrix
- Shogun
- Siedler
- SimCity
- Simon the Sorcerer
- Simpsons - Bart vs. the Space Mutants
- Simpsons - Bart vs. the World
- Sixth Sense Investigations
- Skweek
- Sky High Stuntman
- Skyworker
- Slamtilt Pinball
- Slipstream
- Snake 2000AD
- Soldiers of Fortune
- Soloman's Key
- Solomon's Key
- Somewhere in Time
- Sonic Boom
- Sony Game
- Sorcerer
- Sorcery +
- Space Job
- Spellbound
- Speris Legacy
- Spidertronic
- Spinworld
- Sqrxz 3
- Squeek
- Stadt der Löwen
- Star Goose!
- Star Wars - Return of the Jedi
- Stargoose
- Steg the Slug
- Stone Age
- Stormball
- Stormtrooper
- Strangers
- Street Cat
- Street Fighter 2
- Street Racer
- Stryx
- Sturmtruppen
- Sturmtruppen - the Videogame
- Super Loopz
- Super Nibbly
- Suspect
- SWIV
- Sword of Honour
- Syndicate