3DO - S
- Sailor Moon
- Samurai Shodown
- Scramble Cobra
- Shadow Warriors
- Shanghai - Triple-Threat
- Shockwave
- Shockwave - Operation Jumpgate
- Shockwave 2 - Beyond the Gate
- Slam 'n' Jam '95
- Slayer
- Soccer Kid
- Space Hulk
- Space Pirates
- Star Fighter
- Star Wars - Rebel Assault
- Starblade
- Stellar 7 - Draxon's Revenge
- Super Street Fighter 2 Turbo
- Super Wing Commander
- Supreme Warrior
- Syndicate